Manipulation of Host Gene Expression and Signaling
by Toxoplasma

发布单位:动物医学院发布日期:2018-09-13 浏览次数:

报告人: Laurence David Sibley



       时  间:20189179:00-10:30

       地  点:动医动科大楼401会议室


       电  话:13651265229

             L. David Sibley is the Alan A. and Edith L. Wolff Distinguished Professor in Molecular Microbiology at Washington University School of Medicine, St. Louis. Sibley is a recognized for his work on the cellular and molecular basis of intracellular parasitism and for defining the molecular determinants of pathogenesis that underlie diseases caused by protozoan parasites. Sibley was born in Philadelphia and grew up in Pennsylvania and Ohio. He earned a B.A. degree in biological sciences from Oberlin College in 1978, and a PhD in zoology and physiology from Louisiana State University in 1985. He completed postdoctoral fellowships at the U.S. Public Health Service’s National Hansen’s Disease Center and Stanford University School of Medicine. In 1991, Sibley joined the faculty in the Department of Molecular Microbiology at Washington University School of Medicine, St. Louis. He is a Burroughs-Wellcome Scholar in Molecular Parasitology (2000-2005), a recipient of the Alice and CC Wang Molecular Parasitology Award from the American Society of Biochemistry and Molecular Biology (2017), and a Fellow in the American Academy of Microbiology (2007).

 Research Interests

           My research program is focused on defining adaptations that enable intracellular parasites to gain entry into their host cells, avoid host defenses, and establish a replicative niche. Using Toxoplasma gondii as a model system, we have defined parasite-mediated mechanisms that control host-cell entry and egress, and that mediate tissue migration during parasite dissemination in the host. Together with an extensive group of international collaborators, we have explored genetic diversity and defined the global population structure of this widespread parasite of warm-blooded vertebrates including humans. We have developed a variety of genetic strategies to compare phenotypic differences between natural isolates and to define the molecular basis of pathogenesis. These studies demonstrate that pathogenesis determinants act by altering host gene expression, blocking signaling pathways, and subverting immune responses. Our findings have uncovered novel and essential aspects of parasite biology that provide opportunities for developing new therapies for animal and human diseases.

 Web pagehttp://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=2882

Awards and Honors

1982 - 1985  Louisiana State University Alumni Federation Predoctoral Fellowship

1988 - 1991  Merck Postdoctoral Fellowship, Stanford University

1993 - 1997   Burroughs Wellcome Fund New Investigator Award in Molecular Parasitology

1999 - 2000   Excellence in Mentoring Award, Graduate Student Senate, Washington University

2000 - 2005  Burroughs Wellcome Fund Scholar Award in Molecular Parasitology

2004 - 2005   Excellence in Mentoring Award, Graduate Student Senate, Washington University

2006 -    Alan Kaplan Lecture, University of Kentucky

2007 -    Fellow, American Academy of Microbiology

2007 -    Division AA Lecturer, American Society of Microbiology

2008 -    Molecular, Cellular, and Immunoparasitology Scientific Excellence Award, American Society of Tropical Medicine and Hygiene

2011 -    Howard T. Ricketts Lecture, University of Chicago

2011 - 2012  Distinguished Investigator Award, Washington University School of Medicine

2012 -    Norman D. Levine Lecture, University of Illinois

2012 - 2013  Excellence in Mentoring Award, Graduate Student Senate, Washington University

2012 -    Bruce A.D. Stocker Lecture, Stanford University School of Medicine

2014      Aikawa Memorial Lecture, Case Western Reserve University

2014      Thomson Reuters ISI Highly Cited Researchers List in Microbiology

2017      Alice and C.C. Wang Award In Parasitology, American Society for Biochemistry and Molecular Biology

2017      Member, National Academy of Science


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